"Baxter R","Martin JL",,,,,,,,,"Structure of the Mr 140,000 growth hormone-dependant insulin-like growth factor binding protein complex: Determination by reconstitution and affinity labelling.","Proc Natl Acad Sci","86","6898-6902","1989",,,,"BP igf method","detailed strutural analysis of IGF-BP 150. GH dependant. Alpha, beta and gamma (IGF) subunits.","etal_off","research","copy_on"
"Dawson TP","Gandhi R","LeHir M","Kaissling B",,,,,,,"Ecto-5‘-Nucleotidase: Localization in the Rat Kidney by Light Microscopic Histochemical and Immunohistochemical Methods.","J Histochem Cytochem","37","39–47","1989",,,,"renal","Possible mechs of Glom/Tubeule feedback.","etal_off","research","copy_on"
"Wilkins J","D'Ercole AJ",,,,,,,,,"Affinity labelled plasma somatomedin-C/insulin like growth factor I binding protein. Evidence of growth hormone dependence and subunit structure.","J Clin Invest","75","1350-1358","1985",,,,"igf method","Original work on DSS crosslinking and PAGE.","etal_off","research","copy_on"
"Adams SO","Kapadia M","Mills B","Daughaday WH",,,,,,,"Release of insulin-like growth factors and binding protein activity into serum-free medium of cultured human fibroblasts.","Endocrinol","115","520-526","1984",,,,"igf method","Acid/EtOH & gel extraction. Contradicting previous paper, believes that acid strip NOT enough. Confusing HPLC results. Binding protein assay with DSS.","etal_off","research","copy_on"
"Unterman TG","Patel K","Kumar Mahathre V","Rajamohan G",,,,,,,"Regulation of Low Molecular Weight Insulin-Like Growth Factor Binding Proteins in Experimental Diabetes Mellitus.","Endocrinol 1990b","126(5)","2614","1990",,,,"igf bp","BP assay with Charcoal, ref and method. Problem with stripping off IGF. Good range of methodologies, ligand blots, DSS affinity labelling, Neutral gel analysis.","etal_off","research","copy_on"
"Wang JF","Hampton B","Mehleman T","Burgess WH","Rechler M",,,,,,"Isolation of a Biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors.","Biochem Biophys Res Comms","157(2)","718-726","1988",,,,"bp method","Methods, BP ligand assay c charcoal. CM 2-3 litres. Dialysis vs 0.1M AA. DSS X-link method. Possible that 14k fragment would be difficult to separate off on column.","etal_off","research","copy_on"
"Lamson G","Oh Y","Pham H","Giudice LC","Rosenfeld RG",,,,,,"Expression of two insulin like growth factor binding proteins in a Human endometrial cancer cell line: Structural, Immunological and Genetic characterization.","J Clin Endo Metab","69(4)","852","1989",,,,"bp igf","Good coverage of the FIVE BPs & actions. Differential glycosylation ->apparent diff MWs. Amniotic fluid-hBP25- inhibits mitogenic action ofIGF. ?Paracine action of BP modulating IGF action. Methods - Westernblots.","etal_off","review","copy_off"
"Dawson TP","Wyllie FS","Wynford-Thomas D",,,,,,,,"In Vitro Responsiveness to Serum Growth Factors is inversely related to in vivo malignancy in human thyroid epithelial cells.","Br J Cancer","63","897–900","1991",,,,"GFs thyroid","A paradox....?","etal_off","research","copy_on"
"Hossenlopp P","Seurin D","Segovia-Quinson B","Hardouin S","Binoux M",,,,,,"Analysis of Serum insulin like growth factor binding proteins using Western Blotting: Use of the method for titration of the Binding Proteins and competative binding studies.","Anal Biochem","154","138-143","1986",,,,"method bp","Original Ligand blotting method as used by Zapf.","etal_off","research","copy_off"
"Blum WF","Jenne EW","Reppin F","Keitzzman K","Ranke MB","Bierich JR",,,,,"Insulin-like growth factor I (IGF-I)- binding protein complex is a better mitogen than free IGF-I","Endocrinol","125","766-772","1989",,,,"igf rate","Secretion rate of IGF - BHK 7.5/HSF 24 mg/24hrs/million cells. IGF ata low continuous level promotes mitogenesis. Kd of receptor and BP similar therefore supplies at just right rate. Good description of receptor internalization. Equilibrium explains why","etal_off","research","copy_off"
"Zapf J","Schmid Ch","Guler HP",,,,,,,,"Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF 1 treatment of healthy adults and patients with extrapancreatic tumour.","J Clin Invest","86","952-961","1990",,,,"bp igf","Hossenlopp's ligand blotting method described. Summary of normal serum binding proteins. Hypothesis on regulation of insulin like effects of IGF by localization effects of BPs intravascularly.","etal_off","research","copy_off"
"Unterman TG","Oehler DT","Gotway MB","Harris PW",,,,,,,"Production of the rat type I insulin-like growth factor binding protein by well differentiated H4EIIC3 hepatoma cells: identification, purification and N-terminal amino acid analysis.","Endocinol 1990a","127(2)","789-797","1990",,,,"hepatoma igf","BP assay with PEG and ligand blotting","etal_off","research","copy_off"
"Bachrach LK","Tram T","Goretski P",,,,,,,,"Insulin like growth factors and their binding proteins in human thyroid follicular carcinoma cells.","California IGF Meeting Abstracts",,,"1991",,,,"thyroid igf bp","Gives nebulous figures for production NOT as per cell. FTC 133 & 236 produce minimal IGF but abundant IGF BPs.","etal_off","research","copy_off"
"Mohan S","Bautista CM","Wergedal J","Baylink D",,,,,,,"Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: A potential local regulator of IGF action.","Proc Natl Acad Sci","86","8338-8342","1989",,,,"bp igf","Refs to inhibitory actions of BPs. DSS crosslinking studies. Inhibitory IGF BP found from osteosarcoma cells. Discussion contains good review of inhibitory/stimulatory effects of BPs","etal_off","research","copy_off"
"Minuto F","Barreca A","Del Monte P","Cariola A",,,,,,,"Immunoreactive insulin-like growth factor I (IGF-I) and IGF-I-binding protein content in human thyroid tissue.","J Clin Endocrinol Metab","68(3)","621-626","1989",,,," igf","Norm and MNG studied. Tissue and plasma levels of IGF. Stimulatory effect of TSH is mediated by IGF. IGF levels in MNG>norm. IGF stimulates other GF production - refs. Though no evidence of EGF production.","etal_off","research","copy_off"
"Gelato MC","Gaynes LA","Greenstein","Nissley SP",,,,,,,"Heterogeneity of binding subunits of the human 150k insulin-like growth factor binding protein.","J Clin Endocrin Metab","70(4)","879-887","1990",,,," bp","further evidence for 150k BP made up of multiple subunits with different affinities for IGFs 1 & 2.","etal_off","research","copy_off"
"Lee CY","Henricks DM",,,,,,,,,"Comparisons of various acidic treatments of bovine serum on insulin-like growth factor-I immunoreactivity and binding activity.","J Endocrinol","127","139-148","1990",,,," methods","No abstract available","etal_off","review","copy_on"
"Conver CA",,,,,,,,,,"Potentiation of insulin-like growth factor (IGF) action by IGF bindingprotein-3: Studies of the underlying mechanism.","Endocrinol","130","3191-3199","1992",,,,"igf bp3",,"etal_off","research","copy_off"
"Liu F","Powell DR","Hintz RL",,,,,,,,"Characterization of insulin-like growth factor binding proteins in human serum from patients with chronic renal failure.","J Clin Endocrinol","70","620-628","1990",,,,,,"etal_off","research","copy_off"
"Drop SLS",,,,,,,,,,"On the nomenclature of the insulin-like growth factor binding proteins.","Mol Cell Endocrinol","67","243-244","1989",,,,"bp","Good review","etal_off","review","copy_on"
"Baxter RC",,,,,,,,,,"Circulating levels and molecular distribution of the acid-labile subunit of the high molecular weight insulin-like growth factor-binding protein complex.","J Clin Endocrinol Metab","70","1347-1353","1990",,,,"method bp","150kDa BP has 3 subunits. More info on the beta (binding) unit.","etal_off","research","copy_off"
"Brinkman A","Groffen C","Kortleve DJ","van Kessel AG","Drop SLS",,,,,,"Isolation and characterisation of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).","EMBO J","7","2417-2423","1988",,,,"bp receptors","Fetal IGF-BP MW 30kDa, notes on receptor affinities.","etal_off","research","copy_on"
"Blat C","Delbe J","Villaudy J","Chatelain G","Golde A","Harel L",,,,,"Inhibitory diffusible factor 45 bifunctional activity.","J Bio Chem","264","12449-1245","1989",,,," bp","?? inhibitory BP - 45 kDa.","etal_off","research","copy_off"
"Hill DJ","Camacho-Hubner C","Rashid P","Strain AJ","Clemmons DR",,,,,,"Insulin-like growth factor (IGF)-binding protein release by human fetal fibroblasts: dependency on cell density and IGF peptides.","J Endocrinol","122","87-98","1989",,,,"bp fibroblast","Exogenous IGF stimulates BP production. Sparse cultures release more IGF than confluent. Insulin and hPL cause IGF release.","etal_off","research","copy_on"
"Martin JL","Baxter RC",,,,,,,,,"Insulin-like growth factor-binding protein from human plasma: purification and characterization.","J Biol Chem","261","8754-8760","1986",,,,"igf method","More evidence for 26-22 kDa BP subunits of 150 kDa BP","etal_off","research","copy_on"
"Reeve JG","Payne JA","Bleehen NM",,,,,,,,"Production of immunoreactive insulin growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours.","Br J Cancer","61","727-731","1990",,,,"lung method","Acid/EtOH strip. Commercial RIA (Amersham), immunoradiometric assay, binding protein assay-PAGE with DSS cross-linking.","etal_off","research","copy_off"
"Wang JF","Becks GP","Buckingham KD","Hill DJ",,,,,,,"Characterization of insulin-like growth factor binding proteins secreted by isolated sheep thyroid epithelial cells.","J Endocrinol","125","439-448","1990",,,,"thyroid bp","Good intro. Cultures prod IGF - ref. Methods for BP study - Ligand blot, s-200 gel etc. 10^5 cells in a 24 well dish. NB - acid gel chromatography denatures BP 46 & 30 -> V0 assay NOT accurate.","etal_off","research","copy_on"
"Dawson TP","James R","Williams GT",,,,,,,,"Silicone Plastinated Pathology specimens and their teaching potential.","J Path","162","265–272","1990",,,," teaching","Plastination as an alternative to formalin fixation.","etal_off","research","copy_on"
"Westermark B","Nister M",,,,,,,,,"Molecular genetics of human glioma.","Current Opinion in Oncology","7(3)","220-5","1995",,,,,"This review focuses on genes that have a proven or presumed role in the genesis of astrocytic tumors. A common theme in glioblastoma is the amplification of genes that code for growth factor receptors of the protein-tyrosine kinase family (epidermal grow","etal_off","review","copy_off"
"Chang SM","Prados MD",,,,,,,,,"Chemotherapy for gliomas.","Current Opinion in Oncology","7(3)","207-13","1995",,,,,"Despite advances in surgical and radiation therapy techniques, the prognosis of patients with malignant gliomas remains poor. Few agents have been developed specifically for brain tumors, and the nitrosoureas remain the most active antitumor agents avail","etal_off","review","copy_off"
